Premature menopause and its causes

Premature menopause and its causes

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Menopause occurs when the ovaries no longer produce estrogen, the hormone that controls the reproductive cycle. Anything that damages the ovaries or stops the creation of estrogen can cause premature menopause. This involves a chemotherapy treatment or surgery to remove the ovaries. Many women suffer from early menopause, even if their ovaries are intact.

"The average age for menopause is 51 years according to the National Institute of Aging. Generally, most women experience this problem starting at ages 40 to 60, but early menopause usually refers to cases where it occurs before the age of 40, which is much too much. early, ”explains Dr. Silviu Istoc, primary obstetrics-gynecologist.

There are several known causes of early menopause, although sometimes the cause remains unknown, about which Dr. Silviu Istoc explains below!

Genetic causes

When there is no obvious medical reason for early menopause, the cause is often in the person's gene. Researchers have determined that the age of onset of menopause is most likely inherited. The period when the mother entered menopause can provide clues as to when to start her own menopause.

"If the mother has suffered from premature menopause, then there are six times more chances than the daughter to suffer from the same thing. However, the gene is just one of the causes of early menopause, the simplest and most natural form, compared to the diseases or problems that may have this effect, ”says Dr. Silviu Istoc.


Smoking can contribute to early menopause due to its anti-estrogen effects. Several studies have indicated that long-term smokers are more likely to experience menopause earlier than the average age of onset. On average, smokers start menopause 1-2 years earlier than non-smokers.

"The body mass index is another possible factor in early menopause. Estrogen is stored in adipose tissue. Women with less weight have a lower amount of estrogen, which can be depleted earlier than usual, ”says Dr. Silviu Istoc.

Chromosome defects

Certain defects in chromosomes can lead to early menopause. Turner syndrome is such a problem and occurs when a woman is born with an incomplete chromosome. Women with Turner syndrome have ovaries that do not function properly, often causing them to enter premature menopause.

Autoimmune diseases

Early menopause can be a symptom of an autoimmune disease. These occur when the immune system attacks a part of the body, mistaking it for an invader. Inflammation caused by some autoimmune diseases such as thyroid disease and rheumatoid arthritis can affect the ovaries.

"Menopause begins when the ovaries are no longer functioning properly, and these disorders are hormonal, caused by conditions such as the thyroid. These effects can be known from time to time, following special medical analyzes that show the hormonal disorders in the body and the level at which they are, ”explains Dr. Silviu Istoc.


Epilepsy is a disorder manifested by seizures, which comes from the brain. A number of studies have found that women with epilepsy are more likely to experience premature ovarian failure leading to menopause.

"When menopause starts earlier, the most obvious concern is lack of fertility. However, there are other effects that can lead to health problems and problems. Estrogen raises good cholesterol and lowers harmful ones. blood and strengthens the bone structure, "says Dr. Silviu Istoc.

Loss of estrogen earlier than normal can increase the risk of conditions such as:

- heart disease;

- osteoporosis;

- Parkinson's;

- depression;

- dementia;

- premature death.

Dr. Silviu Istoc is a primary obstetrician-gynecologist at the Medicover Hospital, within the Department of Maternal-Fetal Medicine and Minimally Invasive Gynecological Surgery and at the ProVita Clinic. You can read more details on and on the Facebook page: //

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